Frequency and Causes of Periapical Radiolucency Associated with Post Endodontic Treatment
DOI:
https://doi.org/10.52206/jsmc.2025.15.1.1147Abstract
Background: Periapical radiolucency, often observed in radiographs following inadequate endodontic treatment, is a key radiographic diagnostic marker of periapical pathology.
Objective: To determine the frequency and causes of periapical radiolucency associated with post-endodontic treatment.
Materials and Methods: A cross-sectional descriptive study was conducted on 208 patients who had undergone endodontic treatment, at Saidu College of Dentistry, Swat. Patients aged 15-55 years, presenting with symptoms like pain, tenderness, or sinus formation after treatment, were included. Exclusion criteria were mental impairment, periodontal compromise, pregnancy, and medical conditions impacting bone formation. Radiographs were analyzed to identify periapical radiolucency and its causes such as over-obturation, underfilling, instrument separation, and missed canals. The causes of radiolucency were compared by using the chi-square or Fisher's exact test in R software 4.3.1.
Results: The mean age was 33.85 ± 10.94 years; 58.17% were female. Periapical radiolucency was observed in 48.56% of cases. Among 208 cases, separated instruments were more common in those with periapical radiolucency (12.87%) than without (6.54%), though not statistically significant (p = 0.12). Missed canals were more frequent in cases with radiolucency (33.66%) than without (22.43%; p = 0.071). Resorption rates were similar in both groups (~10%; p = 0.9). A significant association was found with obturation quality (p < 0.001), as over-obturation occurred only in cases with radiolucency (18.81%). Under-obturation was more frequent in cases without radiolucency (91.59% vs. 69.31%), and non-obturation rates were comparable (11.88% vs. 8.41%).
Conclusion: Periapical radiolucency after endodontic treatment is relatively common, often resulting from procedural errors like missed canals and over-obturation.
Keywords: Endodontic treatment, Obturation, Periapical radiolucency, Post-treatment failure, Radiographic assessment.
References
Yapp KE, Brennan P, Ekpo E. Periapical radiography versus cone beam computed tomography in endodontic disease detection: a free-response, factorial study. J Endod 2023;49(4): 419-29. https://doi.org/10.1016/j.joen.2023.02.001
Barati S, Torkzadeh A, Ranjbarian P, Jamshidi ST. Prevalence of periapical radiolucency in endodontically treated teeth with un-treated canals by CBCT. Contemp Orofac Sci 2023;1(3):1-6. https://doi.org/10.30486/cofs.2023.1994617.1015
Albagieh H, Aldosari M, Alkhathlan A, Alfawaz N, Almutairi M. Radiolucent lesions that may resemble inflammatory periapical lesions: a review article. Saudi Dent J 2023;35: 916-19. https://doi.org/10.1016/j.sdentj.2023.11.003
Bhuva B, Ikram O. Complications in endodontics. Primary Dent J 2020;9(4):52-8. https://doi.org/10.1177/2050168420963306
Jiménez-rojas LF, Artaza lP, Pesooti VP, Sellera DP, Alberdi JC. Negotiating and treating lateral canals: a Report of 7 cases. Eur Endod J 2024;9(3):287-94. https://doi.org/10.14744/eej.2023.43265
Holland R, Gomes JE, Cintra LTA, Queiroz ÍOdA, Estrela C. Factors affecting the periapical healing process of endodontically treated teeth. J Appl Oral Sci 2017;25:465-76. https://doi.org/10.1590/678-7757-2016-0464
Scarlatescu SA, Perlea P, Preoteasa C, Gheorghiu IM, Parlatescu I, Nicola G, et al. Controversies and potential medical liability of unintentional canal overfilling of root canal treatments and retreatments in teeth with periapical radiolucency. Rom J Leg Med 2023;31:145-52. https://doi.org/10.1111/iej.13897
Versiani M, Martins J, Ordinola-Zapata R. Anatomical complexities affecting root canal preparation: a narrative review. Austral Dent J 2023;68:S5-S23. https://doi.org/10.1111/adj.12992
Karamifar K, Tondari A, Saghiri MA. Endodontic periapical lesion: an overview on the etiology, diagnosis and current treatment modalities. Eur Endod J 2020;5(2):54–67. https://doi.org/10.14744/eej.2020.42714
Pecora CN, Baskaradoss JK, Al-Sharif A, Al-Rejaie M, Mokhlis H, Al-Fouzan K, et al. Histological evaluation of the root apices of failed endodontic cases. Saudi Endod J 2015;5(2):120-4. https://doi.org/10.4103/1658-5984.155450
Schwendicke F, Göstemeyer G. Single-visit or multiple-visit root canal treatment: systematic review, meta-analysis and trial sequential analysis. BMJ open 2017;7(2):e013115. https://doi.org/10.1136/bmjopen-2016-013115
Estrela C, Holland R, Estrela CRdA, Alencar AHG, Sousa-Neto MD, Pécora JD. Characterization of successful root canal treatment. Braz Dent J 2014; 25(1):3-11. https://doi.org/10.1590/0103-6440201302356
AlRahabi MK. Evaluation of complications of root canal treatment performed by undergraduate dental students. Libyan J Med 2017;12(1):1-6. https://doi.org/10.1080/19932820.2017.1345582
Malagnino VA, Pappalardo A, Plotino G, Carlesi T. The fate of overfilling in root canal treatments with long-term follow-up: a case series. Rest Dent Endod 2021;46(2):e27. https://doi.org/10.5395/rde.2021.46.e27
Tabassum S, Khan FR. Failure of endodontic treatment: The usual suspects. Eur J Dent 2016; 10(01):144-7. https://doi.org/10.4103/1305-7456.175682
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