Comparison of Effectiveness of Dapoxetine vs Placebo for Prolonging Intra Vaginal Ejaculatory Latency Time in Premature Ejaculation

Fazal Elahi, Nizam Uddin, Muhammad Hussain, Amir Amanullah, Niaz Ali


Background: Premature ejaculation (PE) is inability to delay ejaculation sufficiently to enjoy love making which manifests as
occurrence of ejaculation before or very soon after the beginning of intercourse” 1PE concentrate on three criteria: shortened or
nonexistent intravaginal ejaculatory latency time (IELT), usually less than 2 minutes; reduced control over ejaculation; and
decreased satisfaction with intercourse.
Objective: To Compare the effectiveness of dapoxetine versus placebo for prolonging intra vaginal ejaculatory latency time in
premature ejaculation.
Material & Methods: This study was conducted at Department of Urology, institute of Kidney Diseases Hayatabad Medical
Complex, Peshawar. Study Design was randomized controlled trial. Duration of the study was six months (27/2/2015 to 27/8/2015). In this study a total of 188 patients were observed by taking 94 in each group, using 56.5% proportion of improvement in ejaculatory time with Dapoxetine and 35.4% improvement in control group5, 95% confidence interval, 5% level of significance and 90% power of the test with non probability consecutive sampling.
Results: This study shows that in Group A (Dapoxetine) mean age was 33 ± 10.831. Where as in Group B (Placebo) mean age was 32 ± 10.458. More over Dapoxetine was effective in 64(68%) patients while Placebo was effective in 35(37%) patients.
Conclusion: Our study concludes that dapoxetine was more effective than placebo for prolonging intra vaginal ejaculatory in term of latency time in premature ejaculation.


dapoxetine, placebo, intra vaginal ejaculatory, latency time, premature ejaculation

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