Frequency of various Bacteria and their Antibiotics Sensitivity in Neonatal Sepsis at Tertiary Care Hospital

Ihsanul Haq, Salman Mustaan, Ashfaq Ahmad, Sardar Khan, Zahir Said, Sajjad Hussain


Background: Neonatal Sepsis is one of the most common causes of morbidity and mortality particularly in the developing
countries, accounting for 30-50 % of the total death each year. The spectrum of the bacteria that varies and antibiotic resistance is an increasing problem of these bacteria.
Objective: To determine the frequency of various bacteria and their antibiotic sensitivity in Neonatal Sepsis at tertiary care
Material & Methods: This descriptive Cross-sectional study was conducted in Neonatal ICU, Department of Pediatrics, Saidu
Group of Teaching Hospital, Swat, from 1st January 2018 to 30th June 2018. A total number of 350 patients having clinical signs and symptoms of sepsis were enrolled and cultures of blood, urine and CSF were sent to the laboratory with aseptic precautions. Out of these 140 patients with positive cultures were included in the study. The data was collected by random and convenience sampling.
Results: 140 patients were having culture proven neonatal sepsis with culture positivity rate of 40%. Gram Negative Bacteria were the most commonly involved organisms in this study i.e Klebsiella (22.14%) followed by E. Coli (16.42%) and Pseudomonas (12.85%). Staph Aureus (18.57%) was the most common Gram positive isolate followed by Coagulase Negative Strept Cocci (11.42%). Most of the microorganisms isolated were resistant to the commonly used antibiotics like Cefotaxime & Ampicillin.
Conclusions: Neonatal Sepsis is commonly caused by gram negative organisms, which are highly resistant to the commonly used antibiotics including Ampicillin and Cefotaxime. Gram positive organism were observed to have highly sensitive to Vancomycin.


Antibiotic Susceptibility, Early Onset Sepsis, Late Onset Sepsis

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