Efficacy of Short Versus Extended Course of Prophylactic Antibiotic in Clean Surgery

Munir Ahmad, Adnan Reayat, Riaz Ahmad


Background: Prophylactic drugs are one of the measure to prevent surgical site infection. It has been clearly demonstrated that it's impact are significant and guaranteed in all clean contaminated and contaminated surgical procedures.
Objective: To compare the efficacy of short term versus extended course of antibiotic prophylaxis in clean general surgery in terms of surgical site infection.
Material & Methods: This Randomized Control Trail was carried out at the General Surgery Department of Khyber Teaching
Hospital, Peshawar, from 15th June 2016 to 14th May 2018. 1192 patients fulfilling the inclusion criteria were divided randomly into two groups A and B by lottery method. Injection augmentin 1.2g was administered to all patients of both groups at the time of induction of anesthesia, 2nd and 3rd doses after 8 hours and 6 hours respectively. Further antibiotic was stopped from group A and group B started with Tab augmentin 1g twice a day from 2nd post operative day for 5 days. The wound was evaluated for infection on 2nd, 7th, 15th and 30th post operative days in the OPD.
Results: Age range was from 17 to 59 years with mean age of 39.60± 9.46 years in Group A while 35.055± 8.04 years in Group B. Mean BMI was 27.952±2.88 Kg/m2 i n Group A and 27.624±3.30 Kg/m2 in Group B. Mean duration of procedure was 44.664±15.79 minutes in Group A and 48.439±15.79 minutes in Group B. Surgical site infection was observed in 8.4% patients in Group A as compare to 3.4% in Group B.
Conclusion: Short term antibiotic prophylaxis is sufficient to reduce the infection rate of surgical site instead of prolonged use in clean surgery without implant.


Antibiotic Prophylaxis, Prolonged, Short, Clean Surgery, Surgical Site Infection.

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