Correlation of Cardiac Biomarkers and Post-PCI Clinical Outcome done in Cath. Lab of Rehmatul lil Alameen Institute of Cardiology

Najeeb Ullah, Azmat Ihsan Qureshi, Farid Ahmad Chaudhry

Abstract


Background: Increasing mortality risk is associated with the raised CK-MB levels after PCI. The worse cardiac outcome was due to the procedural complication like side branch compromise, flow-limiting dissection and distal embolization. With increased CKMB levels there is an expectancy of adverse clinical outcomes five times more than the normal values.
Objective: To determine the correlation of post PCI clinical outcomes with cardiac biomarkers.
Material & Methods: The present study followed, an observational cohort design. Where a cohort of 110 individuals with angiographic proven ischemic heart disease undergoing PCI were recruited. CK-MB levels were assessed after 24 hours of PCI. Then patients were followed-up for 30 days and mortality / morbidity was noted if occurred. Patients with Acute Myocardial
infarction (MI) (within the last 24 hours), patients with left ventricular systolic dysfunction and all the pregnant females were excluded from the study.
Results: The study contained a cohort of 110 individuals with ischemic heart disease. The cohort was divided into two groups on the basis of CK-MB levels. All the patients in Group A had CK-MB level below to the aforementioned level whereas it was higher than 5.0 in Group B patients. The group A contained 74 patients while the group B had 36 patients. The mean age of all the participants in Group A was 52.5 + 9.9 and in Group B was 55.8+11.98. Among the post PCI complications in group B, one patient (2.7%) died during hospital stay, 10 (27.8%) of the patients had established symptoms of angina within 30 days follow up and were treated accordingly. Non-ST segment elevation myocardial infarction ((NSTEMI) was observed in 5 (13.8%) of the patients. While 4 (10.8%) patients in group B needed a repeat target vessel revascularization.
Conclusions: We may conclude from our study that elevated cardiac biomarkers after PCI may leads or associated with the worse clinical outcomes. This also helps to identify high-risk post PCI groups.

Keywords


Diabetes mellitus (DM), Myocardial infraction (MI), Percutaneous coronary intervention (PCI), Mortality, CK-MB levels.

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