C-Kit (CD-117) Expression in Malignant Phyllodes Tumors of Breast

Authors

  • Ruqaiya Shahid
  • Rubina Gulzar
  • Shahid Pervez

DOI:

https://doi.org/10.52206/jsmc.2019.9.1.%25p

Keywords:

Malignant Phyllodes tumor, Immunohistochemistry, ckit, chemotherapy, treatment, Imitanib mesylate, Gleevac

Abstract

Backgroud: Malignant Phyllodes tumor (MPT) is a fibro epithelial neoplasm of breast, and has an age adjusted incidence rate of
3.1 per one million women. The recurrence rate of MPT reported by various studies varies from 356%, and 27% according to WHO, usually detected within 3 years.

Objective: The objective of this study is to, “Determine the frequency and grading of c-kit (CD-117) immunohistochemical (IHC) expression in 'malignant Phyllodes tumors' of breast in patients presenting to tertiary care hospitalâ€
st st Materials & Methods: This was a descriptive, cross sectional study, conducted from 1 July 2010 to 31 December 2010 in
Histopathology, Pathology and Microbiology departments of, Aga Khan University Hospital (AKUH), Karachi Forty-three
consecutive cases of biopsy proven malignant Phyllodes tumor of breast were stained using ckit antibody by
immunohistochemistry. Grading of ckit immunohistochemical expression was assessed, in neoplastic stromal cells.
Results: Out of these 53.5% (23) were grades 1, 23.3% (10) were grade 2 and 23.3% (10) were grade 3. Further categorizing these, 46.5 % (20) were positive and 53.5% (23) were negative for ckit.
Conclusion: Results of our study showed that 46.55 % of cases of malignant Phyllodes tumor showed positive staining for ckit.
Twenty three% of our cases showed strong staining for ckit and thus are the most likely candidates for targeted treatment against this gene by drugs such as Imatinib mesylate.

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Published

12-06-2019

How to Cite

1.
Shahid R, Gulzar R, Pervez S. C-Kit (CD-117) Expression in Malignant Phyllodes Tumors of Breast. J Saidu Med Coll [Internet]. 2019 Jun. 12 [cited 2025 Apr. 30];9(1). Available from: http://jsmc.pk/index.php/jsmc/article/view/182

Issue

Vol. 9 No. 1 (2019): Journal of Saidu Medical College

Section

Original Article

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