C-Kit (CD-117) Expression in Malignant Phyllodes Tumors of Breast

Ruqaiya Shahid, Rubina Gulzar, Shahid Pervez

Abstract


Backgroud: Malignant Phyllodes tumor (MPT) is a fibro epithelial neoplasm of breast, and has an age adjusted incidence rate of
3.1 per one million women. The recurrence rate of MPT reported by various studies varies from 356%, and 27% according to WHO, usually detected within 3 years.

Objective: The objective of this study is to, “Determine the frequency and grading of c-kit (CD-117) immunohistochemical (IHC) expression in 'malignant Phyllodes tumors' of breast in patients presenting to tertiary care hospital”
st st Materials & Methods: This was a descriptive, cross sectional study, conducted from 1 July 2010 to 31 December 2010 in
Histopathology, Pathology and Microbiology departments of, Aga Khan University Hospital (AKUH), Karachi Forty-three
consecutive cases of biopsy proven malignant Phyllodes tumor of breast were stained using ckit antibody by
immunohistochemistry. Grading of ckit immunohistochemical expression was assessed, in neoplastic stromal cells.
Results: Out of these 53.5% (23) were grades 1, 23.3% (10) were grade 2 and 23.3% (10) were grade 3. Further categorizing these, 46.5 % (20) were positive and 53.5% (23) were negative for ckit.
Conclusion: Results of our study showed that 46.55 % of cases of malignant Phyllodes tumor showed positive staining for ckit.
Twenty three% of our cases showed strong staining for ckit and thus are the most likely candidates for targeted treatment against this gene by drugs such as Imatinib mesylate.


Keywords


Malignant Phyllodes tumor, Immunohistochemistry, ckit, chemotherapy, treatment, Imitanib mesylate, Gleevac

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