Frequency of Hepatoma among Chronic Hepatitis C Virus Infected Patients With Liver Cirrhosis

Shazia Naz, Fareeda Naseer, Mushtaq Ahmad

Abstract


Background: Hepatoma is a high grade malignancy showing rapid infiltrative growth, early stage metastasis, poor therapeutic
response and prognosis even after successful curative resection. Hepatoma is considered as the most common type of primary
liver cancer. Hepatocellular carcinoma occurs most often in people with chronic liver disease, such as cirrhosis caused by hepatitis
B or hepatitis C infection.
Objective: To determine the frequency of hepatoma among chronic hepatitis C virus infected patients with liver cirrhosis.
Material and Method: This study was conducted at Naseer Teaching Hospital Peshawar. It was a descriptive (cross sectional
study) which was conducted for the period of one year from _june 2017 to july 2018 . The total sample size was 113. All the patients
with chronic HCV (minimum five years) having cirrhosis, raised AFP levels (>20ng/ml of blood)and focal lesion or nodule in liver on
ultrasound. Age range between 20 to 60 years and both gender were included. The patients were subjected to liver biopsy as per
international protocols and the specimens were sent in formalin for histopathalogical examination. The exclusion criteria had
strictly followed to control confounders and exclude bias in study result. All the data was stored and analyzed on SPPS version 17.
Results: Our study shows that mean age was 45 years with SD ± 12.24. Fifty nine percent patients were male while 41% patients
were female. Hepatoma was diagnosed in twelve (11%) HCV infected patients with cirrhosis .
Conclusion: This study concluded that in our setup the frequency of hepatoma was 11% in chronic HCV infected patients with
liver cirrhosis


Keywords


hepatoma, chronic hepatitis C virus infected, liver cirrhosis

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