Spectrum of Haematological Abnormalities in Patients of Multiple Myeloma


  • Kiran Aamir
  • Muhammad Hanif
  • Hina Abbas
  • Aamir Ramzan




Multiple myeloma, Anemia, Thrombocytopenia, hematological profile, plasma cell dyscrasia


Background: Multiple myeloma is plasma cell dyscrasia characterized by uncontrolled proliferation of plasma cells and a
distinctive biological behavior. It is an uncommon hematological malignancy which primarily affects older individuals.
Objective: To determine clinico-hematological profile of Multiple Myeloma patients.
Material and Methods: It is a retrospective study conducted at a tertiary care hospital for a period of 6 month in which 55 patients
diagnosed as Multiple myeloma were enrolled. Data of 55 cases of multiple myeloma was analyzed.
Results: Fifty five confirmed cases of MM were identified. There were 44 male and 11 female with a male to female ratio of 2:1. The
frequency of multiple myeloma was high in patients with age 60-69 years. The median age of all patients was 56yrs (range 34-75).
Anemia was present in 96.3% of patients 51% showed thrombocytopenia and 15% showed leucopenia. 91% of patients had ESR
values above 80mm/hr. Serum of 93% patients showed M.band in SPE. Bone marrow of 45.4% patients had 11-20% plasma cells,
marrow of 20% of patients contain 21-60% cells while that of 34.5% patients contain > 60% plasma cells. It was observed that
some of those patients with plasma cells >60% showed severe anemia, severe thrombocytopenia and severe leucopenia.
Radiographic examination showed lytic lesions in all patients
Conclusions: Our analysis shows that clinico-pathological features of multiple myeloma patients in Pakistan are comparable to
published data.




How to Cite

Aamir K, Hanif M, Abbas H, Ramzan A. Spectrum of Haematological Abnormalities in Patients of Multiple Myeloma. J Saidu Med Coll Swat [Internet]. 2020 Jun. 9 [cited 2023 Jan. 27];10(1). Available from: http://jsmc.pk/index.php/jsmc/article/view/271