COMPARITIVE STUDY OF HDL-C LEVEL IN DIABETIC AND NONDIABETIC STROKE SUBJECTS
DOI:
https://doi.org/10.52206/jsmc.2016.6.2.816-820Abstract
BACKGROUND: Diabetes mellitus is a well recognized risk factor for acute stroke, resulting in a
greater ischemic to hemorrhagic stroke ratio in the people with diabetes compared with the general
population. Diabetes also doubles the risk of stroke recurrence and has a poor outcome (or having poor
prognosis for survival) as compared to non-diabetic patients, warranting strong and comprehensive
preventive efforts, The aim of this study was to evaluate the High Density Lipoprotein-Cholesterol
(HDL-C) level in the adult diabetic and non-diabetic stroke patients coming to Medical Unit of Saidu
Teaching Hospital, Swat.
MATERIAL AND METHODOLOGY: This was a cross-sectional study, comprised of 100 subjects,
50 were diabetic and 50 were non -diabetic stroke patients of ages between 40 to 90 years. The study
subjects underwent a detailed history and examination. Individuals with a history of medications known
to affects body composition, patients on anti-coagulants and having a history of blood dyscrasias like
leukemia’s, thalasemia, polycythemia, endocrinopathies and patients having clotting disorders, extradural
and intradural hemorrhage as a cause of stroke were excluded from the study. Fasting as well as random
blood sample were drawn from the participants for biochemical assays. The serum HDL-C level, blood
sugar (random and fasting), blood pressure (systolic and diastolic) of Diabetic stroke subjects were
compared with Non-diabetic stroke subjects.
RESULTS: The HDL-C level was significantly low in our study in diabetic as compared to nondiabetic stroke subjects.
CONCLUSION: The low HDL-C level along with poor metabolic control is an important risk factor
for chronic complications of diabetes mellitus like microvascular and macrovascular disease like
unstable angina, myocardial infarction and stroke. Therefore there is intense need of early screening and
interventions, to prevent macrovascular complications especially stroke in high risk diabetic patients.
KEY WORDS: Diabetes mellitus, High-density Lipoprotein-Cholesterol (HDL-C), Blood pressure,
Stroke.
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