ROLE OF OCTREOTIDE ON OUTCOME OF PATIENTS WITH ACUTE PANCREATITIS

Abstract

BACKGROUND: acute pancreatitis is a multisystem disease carrying broad spectrum of clinical
presentation and complications. The objective of this study was to determine the positive role of
octreotide in the out come of patients suffering from acute pancreatitis.
OBJECTIVE: The objective of this study was to assess the role of octreotide in patients having acute
pancreatitis.
PATIENTS AND METHODS: This is a descriptive, comparative, prospective study. The study was
conducted in the department of surgery Saidu Group of Teaching hospital Saidu Sharif Swat from
January 2011 to June 2014. Total of seventy consecutive patients having acute pancreatitis was
randomized in a prospective trail for the treatment, at tertiary care hospital in Malakand division Swat
KPK Pakistan. The data of patients were recorded on a purposely prepared proforma for this study. The
diagnosis of patients was established on basis of biochemical (serum amylase, WCC, C-reactive protein)
and radiological (USG, CT- scan) investigations. The patients were divided into two groups, A and B.
Group A, had received octreotide along with fluids, omeprazole, analgesic. Group B received fluids,
omeprazole, analgesic without octreotide. Ages of the Group A and B were matched (±5 years). Data
was analyzed using SPSS version 16 employing chi-square test (X" test). A p-value below 0.05 was
considered statistically significant.
RESULTS: In this prospective, comparative study two groups, each of 35 consecutive patients were
selected. The mean age in Group A was 37 ±12.41 years and in Group B 40±10.32 years (p DO.364).
There were 12 males and 23 females in group A, while 14 males and 21 females in group B. Both the
groups were comparable. All the patients in octreotide group A and non-octreotide group B were
survived. No major complications were noted in either group. As far as mean hospital stay was 7 ±2.10
days in group A, while it was 9±3.14 days in group B (p<0.032). All the P- values for the criteria of
study were calculated. P-values were significant when we consider pain control and hospital stay in
two groups.
CONCLUSION: In our study we found that octreotide was more effective in the final outcome of
patients with acute pancreatitis. There is clear cut beneficial effect of octreotide on hospital stay and
reduced need of analgesics in patients having acute pancreatitis.
KEYWORDS: Acute Pancreatitis, Octreotide, Hospital Stay, pain control.