RENAL BIOPSY IN PAEDIATRIC POPULATION
DOI:
https://doi.org/10.52206/jsmc.2013.3.2.314-317Abstract
OBJECTIVE: To find out the pattern of glomerulopathies in paediatric population, undergoing renal
biopsy at Khyber Teaching Hospital, Peshawar.
METHODS: This was a prospective study carried out at the department of Nephrology at Khyber Teaching
Hospital, Peshawar from June 2010 till June 2012. Ultrasound guided percutaneous renal biopsies were
carried out in patients with the finding of; 1 ) Nephrotic range proteinuria in children. 2) Non-Nephrotic
range proteinuria with evidence of hypertension / haematuria / deranged renal function or active sediments
on urine microscopy. 3) Steroid resistant nephrotic syndrome in children (patients not responding to steroid
in eight weeks time) and 4) Children with nephrotic syndrome who were not tolerant of steroid therapy or
were considered for immunosuppressive drugs.
RESULT: A total of 155 renal biopsies were done. Out of these 90 were male patients and 65 were females.
The most common histopathological lesion among children population was minimal change disease
(42.66%) followed by focal segmental glomerulosclerosis (25.33%) and membranous GN (16.0%). We
observed that nephrotic range proteinuria was most prevalent in minimal change disease and membranous
GN followed by focal segmental glomerulosclerosis. While non-nephrotic range proteinuria was mostly
seen in patients with membranoprolifirative GN.
CONCLUSION: In paediatric population, minimal change disease is the most common encountered
glomerulopathy, followed by focal segmental glomerulosclerosisand membranous GN.
KEY WORDS: Nephrotic syndrome, Renal biopsy, Proteinuria, Glomerulopathy
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