Comparison of Onlay vs Sublay Mesh Repair of Anterior Abdominal Wall Hernias; A Randomize Control Trial

Authors

  • Aamir Ali Khan Bacha Khan Medical Complex, Swabi, Pakistan
  • Sahibzada Abdul Basit Bacha Khan Medical Complex, Swabi, Pakistan
  • Muzammil Ahmad Shah Saidu Group of Teaching Hospital, Saidu Sharif, Swat, Pakistan
  • Muhammad Ibrahim Shuja Bacha Khan Medical Complex, Swabi, Pakistan
  • Faisal Zia Bacha Khan Medical Complex, Swabi, Pakistan

DOI:

https://doi.org/10.52206/jsmc.2025.15.1.941

Abstract

Background: Various surgical technique has been developed for anterior abdominal wall mesh placement, including onlay, inlay, sublay, preperitoneal, and intraperitoneal positions. Many advantages and disadvantages are linked to these surgical procedures.
Objectives: To compare onlay and sublay mesh repair techniques for anterior abdominal wall hernias in relation to the mean operative time, post-operative wound infections and seroma formation.
Materials and Method: The study was a randomized control trials, conducted at BKMC Swabi. The study includes 78 patients that were randomly allocated into two groups i.e. 39 patients in Group A (Onlay technique) and 39 in group B (Sublay Technique). Written informed consent was obtained from all participants. Upon enrollment, demographic information was recorded, and detail clinical examinations were conducted.
Results: Group A had a mean age of 43.05 years (SD = 5.385), a mean BMI of 26.46 (SD = 1.144), and an average operation time of 142.18 minutes (SD = 14.017) (p=0.037). In contrast, Group B had a mean age of 42.85 years (SD = 5.284), a mean BMI of 26.18 (SD = 0.885), and a significantly shorter average operation time of 105.77 minutes (SD = 1.307). Age distribution was similar between groups, with around 80% over 40 years old. Gender distribution was slightly more male in Group B (53.8%) compared to Group A (48.7%). ASA class distribution was identical across both groups. Postoperative wound infection rates were higher in Group B (35.9%) compared to Group A (23.1%) (P=0.214). Seroma formation was more common in Group A (46.2%) compared to Group B (35.9%) (P= 0.357).
Conclusion: Sublay repair better in terms of reduced operative time, decreased seroma formation compared to Onlay repair but higher incidence of postoperative wound infections in sublay's procedure should kept under the consideration and proper pre, per-op and post-op wound infections protocols should be followed.
Keywords: Mesh repair, Mean Operative-time, Onlay Technique, Post-operative wound infections, Sublay Technique and Seroma formation.

References

Esievo KAN, Num-Adom SM, Adamu S, Ogbuagu NE, Aluwong T, Umar IA. Elevated serum sialic acids, a potent biomarker of alloxan-induced type 1 diabetes in dogs by ethanolic extract of Anogeissus leiocarpus. J Diabetes Metab Disord 2021; 20:179-86. https://doi.org/10.1007/s40200-021-00726-1

Inim MD, Ibrahim MA, Isah MB, Onyike E. Variations in the mRNA expression level of UDP-GlcNAc epimerase/ManNAc kinase and neuraminidase I genes in organs of type 2 diabetic animals. Glycoconj J 2021;38:129–39. https://doi.org/10.1007/s10719–021-09979–7

Uprety T, Yu J, Nogales A, Naveed A, Yu H, Chen X, Liu Y, et al. Influenza D virus utilizes both 9-O-acetylated N-acetylneuraminic and 9-O-acetylated N-glycolylneuraminic acids as functional entry receptors. J Virol 2024 Mar 19;98(3). https://doi.org/10.1128/jvi.00042-24

Dhar C, Sasmal A, Diaz S, Verhagen A, Yu H, Li W, et al. Are sialic acids involved in COVID-19 pathogenesis?. Glycobiology 2021 Sep;31(9): 1068-71. https://doi.org/10.1093/glycob/cwab063

Ibrahim MA, Isah MB, Inim MD, Abdullahi AD, Adamu A. The connections of sialic acids and diabetes mellitus: therapeutic or diagnostic value?. Glycobiology 2024 Sep;34(9). https://doi.org/10.1093/glycob/cwae053

Kawanishi K, Coker JK, Grunddal KV, Dhar C, Hsiao J, Zengler K, et al. Dietary Neu5Ac intervention protects against atherosclerosis associated with human-like Neu5Gc loss—Brief report. Arterioscler Thromb Vasc Biol 2021 Nov;41(11):2730-9. https://doi.org/10.1161/ATVBAHA.120.315280

Okdahl T, Wegeberg AM, Pociot F, Brock B, Størling J, Brock C. Low-grade inflammation in type 2 diabetes: a cross-sectional study from a Danish diabetes outpatient clinic. BMJ Open 2022;12(12). https://doi.org/10.1136/bmjopen-2022-062188

Oikonomou EK, Antoniades C. The role of adipose tissue in cardiovascular health and disease. Nat Rev Cardiol 2019 Feb;16(2):83-99. https://doi.org/10.1038/s41569-018-0097-6

Li Y, Jin L, Chen T. The effects of secretory IgA in the mucosal immune system. Biomed Res Int 2020 Jan 3;2020:2032057. https://doi.org/10.1155/2020/2032057

Zamboni M, Nori N, Brunelli A, Zoico E. How does adipose tissue contribute to inflammageing?. Exp Gerontol 2021 Jan 1;143:111162. https://doi.org/10.1016/j.exger.2020.111162

Lwanga SK, Lemeshow S. Sample size determination in health studies: A practical manual. Geneva: World Health Organization; 1991. https://iris.who.int/handle/10665/40062

Palinkas LA, Horwitz SM, Green CA, Wisdom JP, Duan N, Hoagwood K. Purposeful sampling for qualitative data collection and analysis in mixed method implementation research. Adm Policy Ment Health 2015;42(5):533–44. https://doi.org/10.1007/s10488-013-0528-y

Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest 2003;111(12):1805-12. https://doi.org/10.1172/JCI200318921

Glanz V, Malik M, Abdul R, Yousuf S, Raza Q. Elevated sialic acid levels and cardiovascular risk in diabetic patients. J Diabetes Complications 2020; 34(7):107-13.

Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/ APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol. Circulation 2019; 139(25). https://doi.org/10.1161/CIR.0000000000000699

Ramdas Nayak VK, Satheesh P, Shenoy MT, Kalra S. Triglyceride glucose (TyG) index: A surrogate biomarker of insulin resistance. J Pak Med Assoc 2022;72(5):986–8. https://doi.org/10.47391/JPMA.22-63

Powers Carson J, Arora J. Glycated serum proteins and albumin but not glycated albumin show negative correlation with BMI in an overweight/obese, diabetic population from the United States. Clin Biochem 2023;120:110654. https://doi.org/10.1016/j.clinbiochem.2023.110654

Kawanishi K, Coker JK, Grunddal KV, Dhar C, Hsiao J, Zengler K, et al. Dietary Neu5Ac intervention protects against atherosclerosis associated with human-like Neu5Gc loss—Brief report. Arterioscler Thromb Vasc Biol 2021 Nov;41(11):2730-9. https://doi.org/10.1161/ATVBAHA.120.315280

Birukov A, Plavcsa B, Eichelmann F, Kuxhaus O, Hoshi RA, Rudman N, et al. Immunoglobulin G –glycosylation signatures in incident type 2 diabetes and cardiovascular disease. Diabetes Care 2022; 45:2729-36. https://doi.org/10.2337/dc22-0833

Glanz VY, Kashirskikh DA, Grechko AV, Yet SF, Sobenin IA, Orekhov AN. Sialidase activity in human blood serum has a distinct seasonal pattern: A pilot study. Biology 2020 Jul 22;9(8):184. https://doi.org/10.3390/biology9080184

Additional Files

Published

29-01-2025

How to Cite

1.
Khan AA, Basit SA, Shah MA, Shuja MI, Zia F. Comparison of Onlay vs Sublay Mesh Repair of Anterior Abdominal Wall Hernias; A Randomize Control Trial. J Saidu Med Coll [Internet]. 2025 Jan. 29 [cited 2025 May 13];15(1):110-5. Available from: http://jsmc.pk/index.php/jsmc/article/view/941