Evaluation of Altered Oral Changes in Covid-19 PCR Positive Cases- A Cross Sectional Study

Authors

  • Tehreem Shahid Rehman College of Dentistry, Peshawar, KP Pakistan
  • Sara Mariyum Swat Medical College, Swat, KP Pakistan
  • Munaza Khattak Peshawar Dental College, Riphah International University, Peshawar, KP Pakistan
  • Shamaila Wadud Peshawar Medical College, Riphah International University, Peshawar, KP Pakistan
  • Farzeen Khan Peshawar Dental College, Riphah International University, Peshawar, KP Pakistan
  • Momina Haq Peshawar Medical College, Riphah International University, Peshawar, KP Pakistan

DOI:

https://doi.org/10.52206/jsmc.2024.14.4.956

Abstract

Background: The Coronavirus Disease caused by SARS-CoV-2 had rapid and worldwide transmission, which resulted in a significant number of fatalities. The virus is known to spread through close contact via exposure to infected droplets and aerosols, and it can infect cells in the upper respiratory tract. However, it was unclear whether the virus directly infects the tissues of the oral cavity and alter oral physiology, resulting in oral symptoms in many COVID-19 patients.
Objective: The present study was performed to evaluate the altered oral changes in covid-19 PCR positive cases.
Materials and Methods: The cross-sectional study was carried out in 211 PCR confirmed patients of SARS-CoV-2. Data was collected using a digital questionnaire for each patient. Saliva was collected through “passive drool” procedure. Both direct samples and extracted RNA were used for qRT-PCR targeting the conserved region of the SARS-CoV-2 genome, the N and ORF1ab genes. Descriptive statistics were computed
Results: There were 211 confirmed patients of COVID-19, out of which 146 (69%) were male and 65 (31%) were female. Regarding oral symptoms in COVID-19 positive patients, Xerostomia and Amblygeustia were commonly reported, with 87% and 90.5% of patients experiencing these symptoms, respectively. Acute parotitis was also reported by 49(23%) patients, indicating that it may be a potential oral symptom of COVID-19.
Conclusion: This study concludes that xerostomia (87%) and amblygeustia(90.5%) are common oral symptoms in SARS-CoV-2 positive patients, and acute parotitis(23%) is also a potential oral symptom.
Keywords: Amblygeustia, COVID-19, Oral, Parotitis, Xerostomia.

References

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J et al. A novel corona virus from patients with pneumonia in China, 2019. New England journal of medicine. 2020;382(8):727-33. DOI: https://doi.org/10.1056/NEJMoa2001017

Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. Journal of medical virology. 2020;92(4):401. DOI: https://doi.org/10.1002/jmv.25678

Zhang R, Li Y, Zhang AL, Wang Y, Molina MJ. Identifying airborne transmission as the dominant route for the spread of COVID-19. Proceedings of the National Academy of Sciences. 2020;117(26):14857-63. DOI: https://doi.org/10.1073/pnas.2009637117

Rehman SU, Shafique L, Ihsan A, Liu Q. Evolutionary trajectory for the emergence of novel corona virus SARS-CoV-2. Pathogens. 2020;9(3):240. DOI: https://doi.org/10.3390/pathogens9030240

Lupia T, Scabini S, Pinna SM, Di Perri G, De Rosa FG, Corcione S. 2019 novel corona virus (2019-nCoV) outbreak: A new challenge. Journal of global antimicrobial resistance. 2020;21:22-7. DOI: https://doi.org/10.1016/j.jgar.2020.02.021

World Health Organization. COVID-19 weekly epidemiological update, edition 134, 16 March 2023.

Corchuelo J, Ulloa FC. Oral manifestations in a patient with a history of asymptomatic COVID-19: Case report. International journal of infectious diseases. 2020;100:154-7. DOI: https://doi.org/10.1016/j.ijid.2020.08.071

Ahn JH, Kim J, Hong SP, Choi SY, Yang MJ, Ju YS et al. Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19. The Journal of clinical investigation. 2021;131(13). DOI: https://doi.org/10.1172/JCI148517

Jung BK, An YH, Jang JJ, Jeon JH, Jang SH, Jang H. The human ACE-2 receptor binding domain of SARS-CoV-2 express on the viral surface of the Newcastle disease virus as a non-replicating viral vector vaccine candidate. PloS one. 2022;17(2): e0263684. DOI: https://doi.org/10.1371/journal.pone.0263684

Wang Y, Kang H, Liu X, Tong Z. Combination of RT-qPCR testing and clinical features for diagnosis of COVID-19 facilities management of SARS-CoV-2 outbreak. Journal of medical virology. 2020;92(6): 538. DOI: https://doi.org/10.1002/jmv.25721

Elamrousy WAH, Nassar M, Issa DR. Prevalence of Oral Lesions in COVID-19 Egyptian Patients. Journal of International Society of Preventive and Community Dentistry. 2021;11(6):712-720. DOI: https://doi.org/10.4103/jispcd.JISPCD_221_21

Ejaz R, Ashraf MT, Qadeer S, Irfan M, Azam A, Butt S, et al. Gender-based incidence, recovery period, and mortality rate of COVID-19 among the population of district Attock, Pakistan. Brazilian Journal of Biology. 2021;83:e249125. DOI: https://doi.org/10.1590/1519-6984.249125

Guggenheimer J, Moore PA. Xerostomia: etiology, recognition and treatment. The journal of the american dental association. 2003;134(1):61-9; quiz 118-9. DOI: https://doi.org/10.14219/jada.archive.2003.0018

Tsuchiya H. Characterization and Pathogenic Speculation of Xerostomia Associated with COVID-19: A narrative review. Dentistry journal. 2021;9(11):130. DOI: https://doi.org/10.3390/dj9110130

Doceda MV, Gavriiloglou M, Petit C, Huck O. Oral Health Implications of SARS-CoV-2/COVID-19: A Systematic Review. Oral Health & Preventive Dentistry. 2022;20(1):207-218. DOI: https://doi.org/10.3290/j.ohpd.b2960801

Riad A, Kassem I, Badrah M, Klugar M. Acute parotitis as a presentation of COVID-19? Oral Diseases. 2022;28 Suppl 1:968-969. DOI: https://doi.org/10.1111/odi.13571

Fisher J, Monette DL, Patel KR, Kelley BP, Kennedy M. COVID-19 associated parotitis. American Journal of Emergency Medicine. 2021;39:254.e1-254.e3. DOI: https://doi.org/10.1016/j.ajem.2020.06.059

Chen L, Zhao J, Peng J, Li X, Deng X, Geng Z, et al. Detection of SARS-CoV-2 in saliva and characterization of oral symptoms in COVID-19 patients. Cell Proliferation. 2020;53(12):e12923. DOI: https://doi.org/10.1111/cpr.12923

Mortazavi H, Rezaeifar K, Nasrabadi N. Oral manifestations of coronavirus disease-19: A mini- review. Open Access Macedonian Journal of Medical Sciences. 2020;8(T1):286-9. DOI: https://doi.org/10.3889/oamjms.2020.4999

Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the corona virus disease (COVID-19): a multicenter European study. European Archives of Oto-rhino-laryngology. 2020;277(8):2251-2261. DOI: https://doi.org/10.1007/s00405-020-05965-1

Mortazavi H, Safi Y, Baharvand M, Rahmani S. Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree. International journal of dentistry. 2016;2016:7278925. DOI: https://doi.org/10.1155/2016/7278925

Additional Files

Published

11-11-2024

How to Cite

1.
Tehreem Shahid, Sara Mariyum, Munaza Khattak, Shamaila Wadud, Farzeen Khan, Momina Haq. Evaluation of Altered Oral Changes in Covid-19 PCR Positive Cases- A Cross Sectional Study. J Saidu Med Coll Swat [Internet]. 2024 Nov. 11 [cited 2024 Dec. 5];14(4):290-5. Available from: http://jsmc.pk/index.php/jsmc/article/view/956