MICROSCOPIC CHANGES IN THE LIVER OF DEVELOPING RATS EXPOSED TO VALPRIOC ACID

Authors

  • MUHAMMAD KHAN
  • INAYAT ULLAH
  • NAIK ZADA
  • MARIYA HIDAYAT

DOI:

https://doi.org/10.52206/jsmc.2015.5.2.685-688

Abstract

BACKGROUND: Valproic Acid (VPA) is a broad - spectrum antiepileptic drug. Its use during
pregnancy has been associated with hapatotoxicity. This study was designed to assess the effects of VPA
on the Microscopic structure of the Liver of developing rats exposed to the drug during various
trimesters of pregnancy.
OBJECTIVE: to evaluate the histological changes in developing liver in rats exposed to valproic acid
during different fetal periods. To correlate the extent of liver injury during various developmental
periods.
MATERIAL AND METHODS: In this Experimental Study pregnant rats were divided in to four
groups A, B, C and D. Group D(n=10) was kept as control group. Group A (n=10) was given VPA in a
dose of 500 mg/kg/day intraperito-nealy (I/P) on days 3, 4, 5 of gestation. Group B (n=10) received the
same dose I/P on days 8, 9, 10 of gestation while Group C (n=10) received the same dose I/P on days
16, 17, and 18 of gestation. On day 21 rats were euthanized and liver of the fetuses were dissected out
for examination.
RESULTS: The central vein was significantly dilated in all the groups. Also, there was significant
increase in the size of hepatocytes in all the groups. Moreover, significant inflammation and congestion
in portal areas and congestion in sinusoids were observed in all the experimental groups.
CONCLUSION: VPA use during pregnancy produces hepatotoxicity in developing rats.
KEY WORDS: Valproic Acid, Developing rats, Hepatotoxicity.

Author Biographies

MUHAMMAD KHAN

Department of Anatomy, Saidu Medical College, Swat.

INAYAT ULLAH

Department of Anatomy, Gajju Khan Medical College, Sawabi.

NAIK ZADA

Department of Anatomy, Saidu Medical College, Swat.

MARIYA HIDAYAT

Department of Anatomy, Rahber Medical College, Lahore.

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How to Cite

1.
MUHAMMAD KHAN, INAYAT ULLAH, NAIK ZADA, MARIYA HIDAYAT. MICROSCOPIC CHANGES IN THE LIVER OF DEVELOPING RATS EXPOSED TO VALPRIOC ACID. J Saidu Med Coll Swat [Internet]. 2021 Mar. 31 [cited 2024 Jul. 12];5(2):685-8. Available from: https://jsmc.pk/index.php/jsmc/article/view/420

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