Chemotherapy: Affected Morphological and Morphometry of Testes and Improvement by Antioxidants
DOI:
https://doi.org/10.52206/jsmc.2022.12.4.695Abstract
Background: Taking into account, the adverse effects of chemotherapy on male fertility, Chemotherapy has been a major area of
concern for physicians. Chemotherapeutic agent Doxorubicin (DOX) profoundly affect the morphometric of testes that is indicative
of damage to this important reproductive organ. Antioxidants being free radical scavenger could be used in order to ameliorate the
Undesirable effect of anti-cancer agents
Objective: To demonstrate change in weight of testes and thickness of germinal epithelium after consumption of Doxorubicin and
to observe the effect of ascorbic acid on these changes
Material and Methods: Experimental study was conducted on mice which were divided in 3 groups A, B and C. They received
saline intraperitoneally (IP), DOX IP and DOX + Ascorbic acid per oral respectively. On completion sacrificed animals were
dissected and testes were weighed and later sections were selected for morphometric measurement of germinal epithelium and
were observed in H&E stained slides under 40x objective and 10x ocular lenses of light microscope
Result: Ascorbic acid seems to be significantly affecting the declined weight of the organ and on disturbed morphometry of
germinal epithelium in mice induced with chemotherapeutic agent DOX
Conclusion: Ascorbic acid seems to be significantly affecting the declined weight of the organ and on disturbed morphometry of
germinal epithelium in mice induced with chemotherapeutic agent DOX
Keyword: Chemotherapy, antioxidant, weight, germinal epithelium, mice.
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