Ameliorative Effect of á Tocopherols on Histomorphological Changes of Testicular Tissues in Adult Rats Exposed to Noise Stress
DOI:
https://doi.org/10.52206/jsmc.2024.14.3.878Abstract
Background: Tocopherols are found to be useful in reducing the harmful effects of noise stress on the histomorphology of the
testicles of rats exposed to noise stress.
Objective: To investigate the protective effects of tocopherol on histomorphology of rats exposed to chronic noise stress.
Materials and Methods: Study was approved by Ethical Review Committee of Army Medical College, Rawalpindi on dated 02-09-2022. It was a Lab based experimental trial conducted for three months. Ninety male albino rats weighing between 250-300g were housed in the NIH animal house. The animals were divided randomly into 3 groups with 30 animals in each group. Group A was a control group, Group B and C were experimental groups. They were undergone a continuous 6-hour daily of chronic noise stress at an intensity of 100 dB, by using an uninterrupted power source. It was offered with a nine-volt standby battery and DC adopter. In addition to noise stress, Group C also received alpha-tocopherol by gastric lavage tube. The Hematoxylin and Eosin (H & E) and Periodic Acid Schiff (PAS) stains were for histopatholgoical studies. Data was analyzed using SPSS version 21.
Results: When compared to control group A, there was a statistically significant difference in various parameters. When compared to experimental group B, the outcomes in tocopherol-treated experimental group C were statistically significant; but, when compared to control group A, they were not statistically significant.
Conclusion: Alpha tocopherol has a protective effect against the negative histomorphological changes caused by noise stress in rat testis.
Keywords: Alpha tocopherol, Antioxidant, Infertility, Noise stress, Sex hormone
References
Van Manh H, Nguyen N-V, Thang PM. An innovative method based on Shannon energy envelope and summit navigation for detecting R peaks of noise stress test signals. Journal of Electrocardiology. 2021;65:8-17. DOI: https://doi.org/10.1016/j.jelectrocard.2020.12.012
Aitken RJ, Drevet JR. The importance of oxidative stress in determining the functionality of mammalian spermatozoa: A two-edged sword. Antioxidants. 2020;9(2):111. DOI: https://doi.org/10.3390/antiox9020111
Patani A, Balram D, Yadav VK, Lian K-Y, Patel A, Sahoo DK. Harnessing the power of nutritional antioxidants against adrenal hormone imbalance-associated oxidative stress. Frontiers in Endocrinology. 2023;14. DOI: https://doi.org/10.3389/fendo.2023.1271521
Pirami H, Khavanin A, Nadri F, Tajpoor A, Mehrifar Y, Tirani ZM. The combined effects of noise and vibration stress on sex hormone levels, fertility capacity, and the protective role of cinnamon extract in rats: an experimental study. Archives of environmental & occupational health. 2022;77(9):764-73. DOI: https://doi.org/10.1080/19338244.2021.2011085
Abouee-Mehrizi A, Rasoulzadeh Y, Kazemi T, Mesgari-Abbasi M. Inflammatory and immunological changes caused by noise exposure: A systematic review. Journal of Environmental Science and Health, Part C. 2022;38(1):61-90. DOI: https://doi.org/10.1080/26896583.2020.1715713
Rahman A, Mirbahari SN, Ahmadi R, Gohari A, Eshghjoo S. Effects of mobile phone radiation and noise pollution on serum levels of LDH, thyroid hormones, liver enzymes, cortisol, and reproductive system in male Wistar rats. Journal of Biological Studies. 2022;5(1 (Special issue)):72-84. DOI: https://doi.org/10.62400/jbs.v5i1.6379
Pirami H, Khavanin A, Mazaheri Z, Nadri F. The protective effect of cinnamon hydroalcoholic extract on testicular tissue changes and fertility capacity in male rats exposed to noise stress. Journal of Birjand University of Medical Sciences. 2018;25(1):21-30. http://journal.bums.ac.ir/article-1-2374-en.html
Al-tai FT. Histological Study of The Effects of Sodium Fluoride and The Protective Role of Vitamin E on The Testis of Albino Rats. Eastern Journal of Medicine. 2023;28(4). DOI: https://doi.org/10.5505/ejm.2023.26429
Masruri B, Alimohammadi I, Abyaz MR, Moghadasi N, Yekzamani P, Asl BM, et al. Concurrent Lead and Noise Exposure Effects on Testicular Tissue of Rat: An Experimental Study. Journal of Family & Reproductive Health. 2022;16(2):132. DOI: https://doi.org/10.18502/jfrh.v16i2.9483
Shabani S, Mehri M, Shirmohammad F, Sharafi M. Enhancement of sperm quality and fertility-related parameters in Hubbard grandparent rooster fed diets supplemented with soybean lecithin and vitamin E. Poultry Science. 2022;101(3):101635. DOI: https://doi.org/10.1016/j.psj.2021.101635
Aitken RJ. Impact of oxidative stress on male and female germ cells: implications for fertility. Reproduction. 2020;159(4):R189-R201. DOI: https://doi.org/10.1530/REP-19-0452
Nowicka-Bauer K, Nixon B. Molecular changes induced by oxidative stress that impair human sperm motility. Antioxidants. 2020;9(2):134. DOI: https://doi.org/10.3390/antiox9020134
Azzi A. Many tocopherols, one vitamin E. Molecular aspects of medicine. 2018;61:92-103. DOI: https://doi.org/10.1016/j.mam.2017.06.004
Beygi Z, Forouhari S, Mahmoudi E, Hayat SM, Nourimand F. Role of oxidative stress and antioxidant supplementation in male fertility. Current Molecular Medicine. 2021;21(4):265-82. DOI: https://doi.org/10.2174/1566524020999200831123553
Bardaweel SK, Gul M, Alzweiri M, Ishaqat A, ALSalamat HA, Bashatwah RM. Reactive oxygen species: The dual role in physiological and pathological conditions of the human body. The Eurasian journal of medicine. 2018;50(3):193. DOI: https://doi.org/10.5152/eurasianjmed.2018.17397
Bisong S, Ukoh I, Nna V, Ebong P. Vitamin E attenuates nicotine-and noise-induced reproductive impairment in male albino Wistar rats. Andrologia. 2018;50(7):e13050. DOI: https://doi.org/10.1111/and.13050
Johnson L, Lebovitz R, Samson W. Germ cell degeneration in normal and microwave-irradiated rats: Potential sperm production rates at different developmental steps in spermatogenesis. The Anatomical Record. 1984;209(4):501-7. DOI: https://doi.org/10.1002/ar.1092090410
Juan CA, Pérez de la Lastra JM, Plou FJ, Pérez-Lebeña E. The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies. International Journal of Molecular Sciences. 2021;22(9):4642. DOI: https://doi.org/10.3390/ijms22094642
Mohammadi H, Golbabaei F, Dehghan SF, Moradi N, Chamari M, Rad MA. Changes in Oxidative Stress Parameters as Response to Supplementation With Vitamin E and Omega-3 Fatty Acids in Male Workers Exposed to High Level Noise. 2021;20 September 2021, Preprint (Version 1) available at Research Square DOI: https://doi.org/10.21203/rs.3.rs-850400/v1
Li Y, Zhang Z, Wang J, Liu C, Liu Y, Jiang X, et al. Effects and possible mechanisms of combined exposure to noise and carbon monoxide on male reproductive system in rats. Environmental Toxicology. 2023;38(12):2926-38. DOI: https://doi.org/10.1002/tox.23927
Roychoudhury S, Chakraborty S, Choudhury AP, Das A, Jha NK, Slama P, et al. Environmental factors-induced oxidative stress: Hormonal and molecular pathway disruptions in hypogonadism and erectile dysfunction. Antioxidants. 2021;10(6):837. DOI: https://doi.org/10.3390/antiox10060837
Abdollahi M-B, Dehghan SF, Balochkhaneh FA, Moghadam MA, Mohammadi H. Comparison of mice'sperm parameters exposed to some hazardous physical agents. Environmental analysis, health and toxicology. 2021;36(3). DOI: https://doi.org/10.1016/j.etap.2018.09.006
Farahbakht E, Alsinani Y, Safari M, Hofmeister M, Rezaie R, Sharifabadi A, et al. Immunoinflammatory Response to Acute Noise Stress in Male Rats Adapted with Different Exercise Training. Noise and Health. 2023;25(119):226-35. DOI: https://doi.org/10.4103/nah.nah_23_23
Additional Files
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 The authors retain the copyrights. Authors are permitted and encouraged to post their work online (e.g. in institutional repositories or on their website), as it can lead to productive exchanges, as well as greater citation of published work.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purpose. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.