Ameliorative Effect of á Tocopherols on Histomorphological Changes of Testicular Tissues in Adult Rats Exposed to Noise Stress

Authors

  • Maria Yousaf Islamic International Medical College, Rawalpindi, Pakistan
  • Humaira Ali Swat Medical College, Swat, Pakistan.
  • Liaqat Ali Swat Medical College, Swat, Pakistan.
  • Nomana Mahmood Wah Medical College, Wah, Pakistan.
  • Fareeha Mushtaq Rawal Institute of Health Sciences, Rawalpindi, Pakistan.
  • Khadija Qamar National University of Medical Sciences, Army Medical College, Rawalpindi, Pakistan.
  • Amna Shoaib Al Nafees Medical College, Islamabad, Pakistan
  • Syed Asad Hasan Al Nafees Medical College, Islamabad, Pakistan.

DOI:

https://doi.org/10.52206/jsmc.2024.14.3.878

Abstract

Background: Tocopherols are found to be useful in reducing the harmful effects of noise stress on the histomorphology of the
testicles of rats exposed to noise stress.
Objective: To investigate the protective effects of tocopherol on histomorphology of rats exposed to chronic noise stress.
Materials and Methods: Study was approved by Ethical Review Committee of Army Medical College, Rawalpindi on dated 02-09-2022. It was a Lab based experimental trial conducted for three months. Ninety male albino rats weighing between 250-300g were housed in the NIH animal house. The animals were divided randomly into 3 groups with 30 animals in each group. Group A was a control group, Group B and C were experimental groups. They were undergone a continuous 6-hour daily of chronic noise stress at an intensity of 100 dB, by using an uninterrupted power source. It was offered with a nine-volt standby battery and DC adopter. In addition to noise stress, Group C also received alpha-tocopherol by gastric lavage tube. The Hematoxylin and Eosin (H & E) and Periodic Acid Schiff (PAS) stains were for histopatholgoical studies. Data was analyzed using SPSS version 21.
Results: When compared to control group A, there was a statistically significant difference in various parameters. When compared to experimental group B, the outcomes in tocopherol-treated experimental group C were statistically significant; but, when compared to control group A, they were not statistically significant.
Conclusion: Alpha tocopherol has a protective effect against the negative histomorphological changes caused by noise stress in rat testis.
Keywords: Alpha tocopherol, Antioxidant, Infertility, Noise stress, Sex hormone

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Additional Files

Published

24-07-2024

How to Cite

1.
Maria Yousaf, Humaira Ali, Liaqat Ali, Nomana Mahmood, Fareeha Mushtaq, Khadija Qamar, Amna Shoaib, Syed Asad Hasan. Ameliorative Effect of á Tocopherols on Histomorphological Changes of Testicular Tissues in Adult Rats Exposed to Noise Stress. J Saidu Med Coll Swat [Internet]. 2024 Jul. 24 [cited 2025 Jan. 17];14(3):218-24. Available from: https://jsmc.pk/index.php/jsmc/article/view/878

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