Obesity, metabolism and the coming Cancer Wave: Why the oncology community must lead a whole-of-society response?
DOI:
https://doi.org/10.52206/jsmc.2026.16.1.1388Abstract
In 2022, more than one billion people worldwide; approximately one in every eight individuals were living with obesity, a prevalence that has doubled among adults and quadrupled among adolescents since 1990 Obesity is no longer merely a lifestyle concern; it represents a global metabolic challenge that is increasingly intersecting with, and amplifying, the burden of cancer. A recent systematic analysis estimates that approximately 356,000 cancer deaths and nearly nine million cancer disability‑adjusted life years (DALYs) in 2021 were attributable to high body mass index (BMI)
References
World Health Organization: WHO. Obesity and overweight 2025. Available at:
https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
Figlioli G, Piovani D, Tsantes AG, Pugliese N, Nikolopoulos GK, Hassan C, et al. Burden of cancer attributable to high body mass index: A systematic analysis of the Global Burden of Disease Study 2021. Clin Nutr. 2025;48:144-152.
https://doi.org/10.1016/j.clnu.2025.04.002
Chen J, Dalerba P, Terry MB, Yang W. Global obesity epidemic and rising incidence of early-onset cancers. J Glob Health. 2024;14:04205.
https://doi.org/10.7189/jogh.14.04205
Global Nutrition Report | Country Nutrition Profiles - Global Nutrition Report. Available at:
https://globalnutritionreport.org/resources/nutrition-profiles/asia/southern-asia/pakistan/
Pati S, Irfan W, Jameel A, Ahmed S, Shahid RK. Obesity and Cancer: A Current Overview of Epidemiology, Pathogenesis, Outcomes, and Management. Cancers (Basel). 2023;15(2):485.
https://doi.org/10.3390/cancers15020485
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569-78.
https://doi.org/10.1016/S0140-6736(08)60269-X
Jenabi E, Poorolajal J. The effect of body mass index on endometrial cancer: A meta-analysis. Public Health. 2015;129:872–880.
https://doi.org/10.1016/j.puhe.2015.04.017
Koh JH, Wang M, Suzuki H, Muthiah M, Ng CH, Huang DQ. NAFLD and NAFLD-related HCC in Asia: Burden and Surveillance. J Clin Exp Hepatol. 2024;14(1):101213.
https://doi.org/10.1016/j.jceh.2023.06.013
Pakistan Ministry of National Health Services, Regulations & Coordination; UNICEF Pakistan. National Nutrition Survey 2018: Key Findings Report. Islamabad: Government of Pakistan; 2019.
Pakistan Ministry of Finance. Excise Duty (Sugar-Sweetened Beverages) Amendment, 2023. Available at:
Itria A, Borges SS, Rinaldi AEM, Nucci LB, Enes CC. Taxing sugar-sweetened beverages as a policy to reduce overweight and obesity in countries of different income classifications: a systematic review. Public Health Nutr. 2021;24(16):5550-5560.
https://doi.org/10.1017/S1368980021002901
Mavromatis LA, Surapaneni A, Mehta S, Xu Y, Chang AR, Velcheti V, et al. Glucagon-like peptide-1 receptor agonists and incidence of obesity-related cancer in adults with diabetes: A target-trial emulation study. Diabetes Obes Metab. 2025;27(8):4571-4575.
https://doi.org/10.1111/dom.16445
Jo H, Ahn S, Ohn JH, Shin CM, Ji E, Kim D, et al. Insulin Resistance and Impaired Insulin Secretion Predict Incident Diabetes: A Statistical Matching Application to the Two Korean Nationwide, Population-Representative Cohorts. Endocrinol Metab (Seoul). 2024;39(5):711-721.
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