DYSLIPIDEMIA IN BETA THALASSAEMIA MAJOR PATIENTS

Abstract

BACKGROUND: Beta thalassaemia is the most common frequent hereditary blood disorder
throughout the world. Changes in lipid levels have been seen in different types of beta thalassaemia.
OBJECTIVE: The aim of study was to evaluate the lipid profile (serum cholesterol, HDL, LDL, serum
triglyceride) in beta-thalassemia major patients and to compare the lipid profile of beta-thalassemia
major patients with healthy controls
MATERIALS AND METHODS: In the present study we included clinically diagnosed 45 patients of
beta thalassaemia major. The levels of Cholesterol, Triglyceride, HDLc, LDLc, VLDLc, were measured
by using latest techniques in clinical biochemistry laboratory.
RESULTS: Our study revealed that in thalassaemic patients lipid pattern became altered had high level
of triglyceride, low level of cholesterol and low HDL-cholesterol levels and conclude that thalassaemic
patients are at risk of coronary heart disease .
CONCLUSION: Significant variations were found which confirm that lipid changes occur in Bthalassaemic patients when Total cholesterol, Serum triglycerides, Low density lipoprotein cholesterol,
high density lipoprotein cholesterol levels are compared with normal healthy subjects. Multiple factors
such as age, iron overload, hormonal changes and liver injury might cause these changes. As this study
focus on lipid abnormalities in beta thalassaemia major, this may help clinicians in the management of
such patients.
KEYWORDS: Total Cholesterol (TC), Triglyceride (TG), High density lipoprotein (HDL), Low
density lipoprotein (LDL), Beta thalassaemia major.