EFFECT OF ALOE BARBADENSIS MILLER WHOLE LEAF EXTRACT ON HYPERGLYCEMIA AND INSULIN RESISTANCE IN LOW DOSE STREPTOZOTOCIN INDUCED TYPE 2 DIABETIC RATS

Authors

  • MEENA GUL
  • MUHAMMAD MAZHAR HUSSAIN
  • AYESHA BABER
  • AMJAD ZAMAN
  • MUSRAT ZAHRA

DOI:

https://doi.org/10.52206/jsmc.2013.3.2.350-355

Abstract

BACKGROUND: Managing diabetes is difficult due to the number of side effects associated with drugs
used for its treatment. There it is a need of an hour to look for indigenous plants which are safe and cost
effective. Present study was planned to determine the effect of Aloe vera whole leaf extract and/or
Rosiglitazone on plasma glucose, insulin and insulin resistance in type 2 diabetic Sprague-Dawley rats.
DESIGN: Randomized control trail
PLACE AND DURATION OF STUDY: This study was conducted from April 2009 to Oct 2010 at the
Department of Physiology Army Medical College, Rawalpindi in collaboration with National Institute of
Health (NIH) Islamabad.
MATERIAL AND METHOD: Type 2 DM was induced in 60 healthy Sprague-Dawley rats by feeding
high fat diet for 2 weeks and injecting a low dose (35mg/kg) of streptozotocin intra peritoneally. Type 2
diabetic rats were randomly divided into four groups, each group having 15 rats and were labeled as diabetic
group, Aloe vera group, rosiglitazone group and combined group. The diabetic group was injected normal
saline, Aloe vera group was treated with Aloe vera whole leaf extract in dose of 300mg/kg body weight,
rosiglitazone group was given 5mg/kg body weight of rosiglitazone I/P and combined group diabetic rats
were treated with 150mg/kg body weight of Aloevera extract and 2.5mg/kg body weight of rosiglitazone
(halfof their effective dose) for 21 days.
RESULTS: A significant reduction (p<0.001) in plasma glucose (73%), insulin (32%) and TG/HDL ratio
(81%) was analyzed in combined groupascompared to diabetic control group. \
CONCLUSION: The maximum impact in lowering plasma glucose, insulin and TG/HDL ratio was
recorded in combined group, followed by rosiglitazone group and then Aloevera group.
KEYWORDS:T2DM. Aloe vera, insulin resistance

Author Biographies

MEENA GUL

Physiology Department, Khyber Girls Medical College, Peshawar



MUHAMMAD MAZHAR HUSSAIN

Physiology Department, Army Medical College, Rawalpindi.



AYESHA BABER

Physiology Department, Usra Medical College, Rawalpindi.



AMJAD ZAMAN

Physiology Department, Khyber Girls Medical College.



MUSRAT ZAHRA

Physiology Department, Khyber Girls Medical College, Peshawar.



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How to Cite

1.
MEENA GUL, MUHAMMAD MAZHAR HUSSAIN, AYESHA BABER, AMJAD ZAMAN, MUSRAT ZAHRA. EFFECT OF ALOE BARBADENSIS MILLER WHOLE LEAF EXTRACT ON HYPERGLYCEMIA AND INSULIN RESISTANCE IN LOW DOSE STREPTOZOTOCIN INDUCED TYPE 2 DIABETIC RATS. J Saidu Med Coll [Internet]. 2013 Apr. 20 [cited 2026 Nov. 10];3(2):350-5. Available from: http://jsmc.pk/index.php/jsmc/article/view/509

Issue

Vol. 3 No. 2 (2013): Journal of Saidu Medical College

Section

Original Article

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