Association of Serum Soluble E-Cadherin Levels with Oral Potentially Malignant Disorders in Tobacco Users and Non-Users
DOI:
https://doi.org/10.52206/jsmc.2021.11.3.652Abstract
Background: Oral Potentially Malignant Disorders (OPMDs) transforms into Oral Squamous Cell Carcinoma (OSCC) but this
transformation is not steadfast and depends on multiple factors. E-cadherin, a calcium-dependent cell-cell adhesion molecule
plays pivotal role in epithelial cell behavior, tissue formation, and suppression of cancer and participates in signal transduction of
various cellular events including polarity, differentiation, growth and migration. The serum E-cadherin level are raised in cancer
patients
Objective: We designed the study to compare soluble E-cadherin levels in the serum of patients with OPMDs and healthy control
amongtobacco users and non-users.
Material and Methods: This comparative cross sectional study was conducted at Peshawar Dental College, Khyber College of
Dentistry,and Bacha Khan Dental College on the serum samples of 80 subjects, comprising of40 cases of OPMDs and40 healthy
controls,by adoptingnon-probability consecutive samplingtechnique.
The serum was analyzed for soluble E-cadherin levels/concentration by ELISA method. Data was recorded, evaluated and
analyzed by SPSS version 23.
Results:In OPMDs (Group A) 29 (72.5 %) were tobacco user and 11 (27.5 %) were non-users while in healthy controls (Group B)
only 7 (17.5 %) were tobacco user and 33 (82.5 %) were non-users
The mean serum soluble E-cadherin levels among OPMDs andhealthy controls were 25.94 ng/mL(SD of ±4.65), 24.10ng/mL (SD
of ±6.21) respectively. It was statistically insignificant (P>0.05) and were identified when independent samples T-Test were applied
to compare the serum soluble E-cadherin levels between the two groups. Statistically significant (P<0.05) relation has been
established in our study between tobacco users and OPMDs. By using Chi square test both tobacco users and non-users, males
and females showed highly significant association with OPMDs group and healthy controls with a (P<0.05) respectively
Conclusion: The concentration of serum soluble E-cadherin were higher in OPMDs cases when compared with healthy controls
both tobacco users and non-users but it was found statistically insignificant. Furthermore, the serum soluble E-cadherin with
OPMDs group had a significant association with tobacco user. Risk estimate (odds ratios) showed that tobacco users were 12.43
times more at riskto develop OPMDs thannon-users
Keywords: Oral Potential Malignant Disorders (OPMDs), Serum soluble E-cadherins,Oral Squamous CellCarcinoma (OSCC).
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