Relationship between CRP, Sialic Acid and Lipid Profile in Hospitalized Patients with Type 2 Diabetes
DOI:
https://doi.org/10.52206/jsmc.2025.15.1.924Keywords:
: sialic acid, crp, lipid profile, diabetic, age group, diabetes.Abstract
Background: Experimental evidence suggests that several molecular pathways may be involved in the development of micro vascular and macro vascular issues in individuals with diabetes. Type 2 diabetes is predicted by elevated levels of acute-phase reactants such sialic acid and reactive protein (CRP).
Objective: This study aimed to explore the relationship between sialic acid, lipid profile, and CRP levels across different age groups and diabetes statuses.
Materials and Methods: A retrospective cohort study was conducted at Mardan Medical Complex, Khyber Pakhtunkhwa, Pakistan, from January 2023 to December 2023. Data were collected from patients based on demographic characteristics, including age (17–25, 25–35, and 35–50 years) and diabetes status (newly diagnosed vs. long-term). Biomarker levels of lipid profile, sialic acid, and C-reactive protein (CRP) were classified as high or normal. Statistical analysis was performed using SPSS version 26, with chi-square tests and logistic regression applied to examine associations between biomarker levels and demographic variables.
Result: Elevated CRP levels were prevalent across all age groups, with 65.6% of patients showing high levels (p < 0.05). Sialic acid levels varied significantly among age groups, with individuals aged 35–50 years showing higher normal levels (43.2%) compared to younger groups (p = 0.02). Dyslipidemia was more common in the 35–50 age group, with 58.7% exhibiting abnormal lipid profiles, compared to 27.1% in the 17–25 age group (p = 0.01). Newly diagnosed diabetics had significantly higher levels of both sialic acid and CRP (72.4%) compared to long-term diabetics (48.6%) (p = 0.03), indicating distinct inflammatory and metabolic profiles between these groups.
Conclusion: The findings underscore the importance of assessing cardiovascular risk factors with respect to age and diabetes status. Age-related differences in metabolic and inflammatory biomarkers, as well as distinctions between newly diagnosed and long-term diabetics, were evident. These insights can help guide targeted interventions and personalized management plans to improve outcomes for patients at risk of cardiovascular complications.
Keywords: Age Groups, C-Reactive Protein, Diabetes Mellitus, Lipid Profile, Sialic Acids, Type 2.
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