AMELIORATIVE EFFECTS OF MGS04 ON DEXAMETHASONE- INDUCED HISTO-CHEMICAL ALTERATIONS IN THE TESTES OF ALBINO RATS

Authors

  • INAYATULLAH
  • MOHAMMAD KHAN
  • MARIYA HIDAYAT
  • LUTFUR-RAHMAN
  • ASMA SIDDIQUI
  • YASMEEN MAHAR

DOI:

https://doi.org/10.52206/jsmc.2016.6.1.753-757

Abstract

BACKGROUND: In experimental animal, dexamethasone-induced impaired spermatogenesis causes
disruption of the normal architecture of seminiferous tubules and alteration in male sexual hormone
testosterone. Concomitant administration of MgS04 preserved the cytoarchitecture of testes as well as
hormonal regulation in albino rats.
OBJECTIVE: This study was designed to observe the ameliorative effects of MgS04 on the histology
of testes and there correlation with serum testosterone level during dexamethasone administration in
albino rats.
METHODOLOGY: This experimental study was conducted in the department of Anatomy, Basic
A L
Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC), Karachi from 5 April
to 25th April 2012. Thirty healthy male adult albino rats were included in the study and divided equally
into 3 groups. Each group comprising 10 animals. Group-A served as Control. Group-B received
Dexamethasone (intraperitonealy) at the dose of 4mg/kg body weight/24 hours. Group-C received
Dexamethasone at the same dose as in group-B and additionally given MgS04 (intramuscularly) at the
dose of 20mg/kg/24hours.
RESULTS: MgS04 significantly preserved the cytoarchitecture of testes, as well as minimized
alteration in serum testosterone level in group-C animals.
CONCLUSION: MgSO4 has restored both the histological and biochemical damaging effects induced
by dexamethasone in Rats testes.
KEYWORDS: Dexamethasone, MgS04, Testicular tissue, Testosterone.

Author Biographies

INAYATULLAH

Department of Anatomy, Gajju Khan Medical College, Swabi.

MOHAMMAD KHAN

Department of Anatomy, Saidu Medical College, Swat

MARIYA HIDAYAT

Department of Anatomy, Rahbar Medical and Dental College, Lahore.

LUTFUR-RAHMAN

M.Phil student of Biotechnology, Quaide-I-azam University, Islamabad.

ASMA SIDDIQUI

Department of Anatomy, Bahria University Medical & Dental College, Karachi

YASMEEN MAHAR

Department of Anatomy, Bahria University Medical & Dental College, Karachi.

Downloads

How to Cite

1.
INAYATULLAH, MOHAMMAD KHAN, MARIYA HIDAYAT, LUTFUR-RAHMAN, ASMA SIDDIQUI, YASMEEN MAHAR. AMELIORATIVE EFFECTS OF MGS04 ON DEXAMETHASONE- INDUCED HISTO-CHEMICAL ALTERATIONS IN THE TESTES OF ALBINO RATS. J Saidu Med Coll [Internet]. 2016 Jun. 30 [cited 2026 Nov. 10];6(1):753-7. Available from: http://jsmc.pk/index.php/jsmc/article/view/406

Issue

Vol. 6 No. 1 (2016): Journal of Saidu Medical College

Section

Original Article

License

Copyright (c) 2021 The authors retain the copyrights. Authors are permitted and encouraged to post their work online (e.g. in institutional repositories or on their website), as it can lead to productive exchanges, as well as greater citation of published work.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purpose. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.