THYROXINE PRESERVES THE ARCHITECTURE OF PANCREATIC ISLETS OF LANGERHANS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Authors

  • MARIYAH HIDAYAT
  • INAYATULLAH
  • YASMEEN MAHAR
  • MOHAMMAD KHAN

DOI:

https://doi.org/10.52206/jsmc.2015.5.1.586-590

Abstract

BACKGROUND: In experimental animal models, Streptozotocin (STZ) induced diabetes, causes
disruption of the normal architecture of the islets of Langerhans and exogenous administration of
thyroxine in diabetic rats preserves the anatomy of endocrine pancreas.
OBJECTIVE: This study was performed to observe the effect of thyroxine on the pancreas of albino
rats during STZ induced diabetes.
MATERIAL AND METHODS: This is a Prospective experimental study was conducted in Anatomy
department at BMSI, JPMC, Karachi from 01 November to 15 December 2013. In this study sixty
healthy adult albino rats were included in the study and divided equally into 3 groups for 6 weeks.
Group-A was taken as control. Group-B received STZ (I/P) in a dose of 37 mg/kg body weight. GroupC received STZ in the same dose and additionally received thyroxine (1 mg/kg (s.c.) thrice a week for 6
weeks.
RESULTS: STZ significantly increased serum glucose level and decreased weight in group B animals,
whereas in group C, thyroxine significantly restored serum glucose level but could not restore the body
weights reduced by streptozotocin. Moreover, thyroxine significantly preserved the morphology of
pancreatic islets in group C animals.
CONCLUSION: Thyroxine restores the structure of pancreatic islets distorted by STZ and reduces
hyperglycemia, but cannot restore the body weight.
KEYWORDS: Streptozotocin, Thyroxine, Diabetes Mellitus, Hyperglycaemia, islets of Langerhans, Albino rats.

Author Biographies

MARIYAH HIDAYAT

Department OF Anatomy, Rahbar Medical and Dental College, Lahore.



INAYATULLAH

Department OF Anatomy, Gajju khan Medical College, Swabi.



YASMEEN MAHAR

Department OF Anatomy, Bahria University of Medical and Dental College, Karachi.



MOHAMMAD KHAN

Department of Anatomy, Saidu Medical College, Swat.



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How to Cite

1.
MARIYAH HIDAYAT, INAYATULLAH, YASMEEN MAHAR, MOHAMMAD KHAN. THYROXINE PRESERVES THE ARCHITECTURE OF PANCREATIC ISLETS OF LANGERHANS IN STREPTOZOTOCIN INDUCED DIABETIC RATS. J Saidu Med Coll [Internet]. 2015 Apr. 1 [cited 2026 Nov. 10];5(1):586-90. Available from: http://jsmc.pk/index.php/jsmc/article/view/428

Issue

Vol. 5 No. 1 (2015): Journal of Saidu Medical College

Section

Original Article

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