COMPARISON BETWEEN THE EFFECTS OF EXTRACT FROM MEDICINAL PLANT OLEA EUROPEA AND VERAPAMIL ON STIMULATED GASTRIC SECRETION IN FASTING RABBITS

Authors

  • Muhammad Jan
  • Hidayatur-Rahman
  • Alamzeb
  • Shafiq Tariq
  • Masood-ur- Rehman

DOI:

https://doi.org/10.52206/jsmc.2011.1.1.12-15

Abstract

Background: Peptic ulcer is mostly produced due to the over production of gastric acid. This study was
designed to find out the effects of extract from the leaves of medicinal plant Olea europea (which contains
documented natural Calcium channel blocker) and Verapamil on volume and acidity of Carbachol induced
gastric section. Their effects were also compared to find out any difference in their efficacy.
Methods: Thirty rabbits of local breed, weighing 1-1.5kg were used. The animals were kept fasting for 48
hours, after which the pylorus of each animal was ligated. Verapamil 10 mg/kg, Olea europea 500 mg/kg and
Carbachol 600 g/kg body weight were administered intraperitoneally.
Results : It was found that Verapamil reduced the volume, free and total acidity of gastric secretion, which
were statistically highly significant when compared with Carbachol (P<0.001). The extract also had the
same effects, when the difference of mean for Verapamil was compared with that of extract, all these
differences were found statistically significant(p<0.05) indicating that the extract has less effect as
compared to Verapamil on all parameters included in the study.
Conclusion: The extract from the leavesof Olea europea therefore, may be used effectively in the treatment
of peptic ulcer and all other conditions like angina, myocardial infarction, hypertension, prevention of
premature labor and bronchial asthma which require calcium channel blockers for the treatment of these
disorders.

Author Biographies

Muhammad Jan

Department of Pharmacology Saidu Medical College Saidu Sharif Swat

Hidayatur-Rahman

Department of Forensic Medicine Saidu Medical College Saidu Sharif Swat

Alamzeb

Department of Physiology Saidu Medical College Saidu Sharif Swat

Shafiq Tariq

Department of Pharmacology Khyber Medical College Peshawar

Masood-ur- Rehman

Ministry of Health Islamabad

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How to Cite

1.
Muhammad Jan, Hidayatur-Rahman, Alamzeb, Shafiq Tariq, Masood-ur- Rehman. COMPARISON BETWEEN THE EFFECTS OF EXTRACT FROM MEDICINAL PLANT OLEA EUROPEA AND VERAPAMIL ON STIMULATED GASTRIC SECRETION IN FASTING RABBITS. J Saidu Med Coll [Internet]. 2011 Jun. 17 [cited 2026 Nov. 10];1(1):12-5. Available from: http://jsmc.pk/index.php/jsmc/article/view/603

Issue

Vol. 1 No. 1 (2011): Jounral of Saidu Medical College

Section

Original Article

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