COMPARISON BETWEEN THE EFFECTS OF EXTRACTS FROM THREE MEDICINAL PLANTS “ AMMI VISNAGA, MYRISTICA FRAGRANS AND OLEA EUROPEA†ON STIMULATED GASTRIC SECRETION IN FASTING RABBITS.
DOI:
https://doi.org/10.52206/jsmc.2015.5.1.648-651Abstract
BACKGROUND: Peptic ulcer is mostly produced due to the over production of gastric acid. This
study was undertaken to find out the effects of extract from the fruits of medicinal plants Ammi visnaga,
seeds of Myristica fragrans and leaves of Olea europea (all of which contain documented natural
Calcium channel blockers) on volume and acidity of Carbachol induced gastric section. Their effects
were also compared to find out any difference in their efficacy.
OBJECTIVE: To find out the comparative effectiveness of three medicinal plants extracts for the
treatment of peptic ulcer and disease associated with hyper gastric acidity conditions.
MATERIAL & METHODS: Forty rabbits of local breed, weighing 1-1.5kg were used. The animals
were kept on fasting for 48 hours, divided into group A, B, C & D. pylorus of each animal was ligated
after a midline incision. Each extracts 500 mg/kg body weight and Carbachol 600pg/kg body weight
were administered in traperitoneally.
RESULTS: It was found that all the extracts reduced the volume, free and total acidity of gastric
secretion, which were statistically highly significant when compared with Carbachol (PcO.OOl). By
observing the mean values of all the extracts, it was clear that Ammi visnaga was more effective than
Myristica fragrans which was in turn more effective than Olea europea on all parameters included in
study.
CONCLUSION: The three extracts therefore, can be used effectively in the treatment of peptic ulcer
and all other diseases associated with hyper gastric acidity.
KEY WORDS: Extracts & gastric secretion
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