COMPARATIVE EFFECTS OF PLANT EXTRACT ON GASTRIC SECRETION
DOI:
https://doi.org/10.52206/jsmc.2013.3.2.331-334Abstract
OBJECTIVE: To compare the effects of extracts from medicinal plantsAmmi Visnaga & Olea eurpea on
Volume and acidity of stimulated gastric secretion in rabbits.
METHODS: The present study was carried out in department of
Pharmacology & therapeutics, Saidu Medical College Swat Pakistan between July 2008 to June 2009.
Thirty rabbits weighing 1-1 ,5kg were included. They were divided in to groups A, B &C each having 10
animals. After fasting for 48 hours, pylorus of each animal was ligated. To group A Carbachol, group B
extracts of Ammi visnaga and group C Olea europea followed by Carbachol after 15 minutes to groups B &
C were administered intraperitoneally. After 4 hours, stomach was removed, volume was measured,
contents centrifuged & estimation for acidity was done by method of titration. Data was subjected to
statistical analysis.
RESULTS: In groups B & C, reduction in volume, free and total acidity of gastric juice was observed. All
these reductions were found statistically highly significant when their means were compared with that of
groupA(P <0.001).
CONCLUSION: Extracts can be used effectively in the treatment of hyper acidity conditions and peptic
ulcer after evaluation of their effects in human being.
KEYWORDS: Ammi Visnaga, Olea Europea, gastric acid secretion.
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