COMPARISON BETWEEN THE EFFECTS OF EXTRACT FROM MEDICINAL PLANT “ AMMI VISNAGA AND CIMETIDINE ON THE VOLUME AND ACIDITY OF STIMULATED GASTRIC SECRETION IN FASTING RABBITS.
DOI:
https://doi.org/10.52206/jsmc.2012.2.2.165-168Abstract
Background: Peptic ulcer is mostly produced due to the over production of gastric acid. This study was
undertaken to find out the effects of extract from medicinal plant “ Ammi visnaga†(which contains
documented natural Calcium channel blocker) and Cimetidine on volume and acidity of Carbachol induced
gastric section. Their effects were also compared to find out any difference in their efficacy.
METHODS: Thirty rabbits of local breed, weighing 1-1 ,5kg were used. The animals were kept on fasting
for 48 hours, after which the pylorus of each animal was ligated. Cimetidine 2.5 mg/kg, Ammi visnaga, 500
mg/kg and Carbachol 600g/kg body weight were administered intraperitoneally.
Results: It was found that Cimetidine reduced the volume, free and total acidity of gastric secretion, which
were highly significant when compared with Carbachol ( P<0.001). The extract also had the same effects.
When the difference of mean for Cimetidine was compared with that of extract, all these differences were
found non-significant indicating that the extract has similar effect as that of Cimetidine on all parameters
included in the study.
Conclusion: The extract from the fruits of Ammi visnaga therefore, be used effectively in the treatment of
peptic ulcer and all other conditions like angina, myocardial infarction and hypertension which require
calcium channel blockers for their treatment.
Key words: Ammi visnaga, Zollinger-Ellison (Z.E) syndrome
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