COMPARISON BETWEEN THE EFFECTS OF EXTRACT FROM MEDICINAL PLANT“OLEA EUROPEA†AND MYRISTICA FRAGRANS ON THE VOLUME AND ACIDITY OF CARBACHOL INDUCED GASTRIC SECRETION IN FASTING RABBITS.
DOI:
https://doi.org/10.52206/jsmc.2014.4.1.446-449Abstract
BACKGROUND: Peptic ulcer is mostly produced due to the over production of gastric acid. This study
was undertaken to find out the effects of extracts from medicinal plants Olea europea and Myristica
fragrans (Both of them contains documented natural Calcium channel blocker) on volume and acidity of
Carbachol induced gastric section.
METHODS: Thirty rabbits of local breed, weighing 1-1.5kg were used. The animals were kept on
fasting for 48 hours. After general anesthesia, pylorus of each animal was ligated. Both the extracts 500
mg/kg each and Carbachol 600| ig/kg body weight after 15 minutes were administered intraperitoneally.
RESULTS : When the means of all the parameters were compared with that of carbachol, it was found
that the extracts reduced the volume, free and total acidity of gastric secretion which were statistically
highly significant (P<0.001). When we compared the mean values of volume, free and total acidity for
the two extracts, it was observed that these differences in all the three parameters between groups B and
C were found to be non-significant (P>0.5).
CONCLUSION: The extracts can be used effectively and safely in the treatment of hyper acidity
conditions and peptic ulcer after evaluation its effects in human being.
KEY WORDS: Olea europea, Myristica fragrans & gastric secretion.
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