COMPARISON BETWEEN THE EFFECTS OF EXTRACT FROM MEDICINAL PLANT “ AMMI VISNAGA AND MYRISTICA FRAGRANS†ON THE VOLUME AND ACIDITY OF CARBACHOL INDUCED GASTRIC SECRETION IN FASTING RABBITS.
DOI:
https://doi.org/10.52206/jsmc.2014.4.2.533-536Abstract
BACKGROUND: Peptic ulcer is mostly produced due to the over production of gastric acid. This study
was undertaken to find out the effects of extract from the fruits of medicinal plant Ammi visnaga and
seeds of Myristica fragrans (both of which contain documented natural Calcium channel blockers) on
volume and acidity of Carbachol induced gastric section. Their effects were also compared to find out
any difference in their effect.
DESIGN: Quasi experimental.
PLACE & DURATION OF STUDY: Pharmacology Department Saidu Medical College Swat.
METHODS: Thirty rabbits of local breed, weighing 1-1.5kg were used. The animals were kept on
fasting for 48 hours, after which the pylorus of each animal was ligated. Carbachol 600iig/kg was
injected to group A Extracts of Ammi visnaga and Myristica fragrans 500 mg/kg body weight each and
after 15 minutes Carbachol 600jlg/kg body weight was administered to group B & C intraperitoneally.
RESULTS: It was found that both the extracts reduced the volume, free and total acidity of gastric
secretion, which were statistically highly significant when compared with Carbachol ( PcO.OOl). When
the differences of means for both the extracts were compared, all these were found statistically non
significant indicating that the extracts have similar effects on all parameters included in study.
CONCLUSION: The extracts can be used effectively and safely in the treatment of hyper acidity
conditions and peptic ulcer after evaluation of their effects in human.
KEY WORDS: Ammi visnaga & Myristica fragrans, gastric secretion.
Downloads
How to Cite
Issue
Section
License
Copyright (c) 2021 The authors retain the copyrights. Authors are permitted and encouraged to post their work online (e.g. in institutional repositories or on their website), as it can lead to productive exchanges, as well as greater citation of published work.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purpose. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
